Lithium Neurotoxicity at ‘therapeutic’ Levels a Case Report
نویسندگان
چکیده
A case of a young manic patient who developed severe neurotoxicity when on lithium alone has been presented. Investigations did not reveal presence of any infection, electrolyte imbalance or rise in lithium level.The possibility of lithium producing neurotoxicity at therapeutic levels for as yet unknown reasons is pointed out. It is suggested that this element of risk be considered when starting lithium for therapy or prophylaxis of affective disorders.
منابع مشابه
Lithium neurotoxicity.
The peripheral and central neurotoxic effects of lithium carbonate are illustrated by 4 case histories. Lithium neurotoxicity is likely to be more common than the literature suggests. Neurological sequelae may be irreversible and may be associated with therapeutic serum levels. Prevention may be facilitated by more stringent case selection, EEG and clinical monitoring and the development of imp...
متن کاملTeaching neuroimages: reversible paradoxical lithium neurotoxicity.
A 33-year-old man with bipolar affective disorder presented with acute onset of rigidity, tremors, and confusion. He had been taking oral lithium (1,200 mg daily) for the past 2 months. Baseline blood, EEG, and CSF analyses were normal. Serum lithium level was 0.67 mEq/L (0.3–1.3). GadoliniumMRI brain showed multiple bilateral symmetric T2-weighted hyperintensities (figure, A–C). On suspicion o...
متن کاملCerebellar Damage in a Patient on Lithium Developing Enteric Fever : a Case Report
The effects of lithium on the CNS range from commonly observed mild effects to life threatening, irreversible brain damage in rare instances of severe toxicity (Moore 1972, Hartitzach et al 1972, Reisberg & Gershon 1979, Kadgoanker et al 1981). Some of the common side effects include mild cognitive impairment, muscular weakness, tremors and EEG changes. Neurotoxicity usually presents with cloud...
متن کاملLithium Toxicity and Neurologic Effects: Probable Neuroleptic Malignant Syndrome Resulting from Lithium Toxicity
Introduction. We present the case of a patient who developed lithium toxicity with normal therapeutic levels, as a result of pharmacokinetic interaction with Valsartan, and probable Neuroleptic Malignant Syndrome from the ensuing lithium toxicity. Case Presentation. A 59-year old black male with bipolar disorder maintained on lithium and fluphenazine therapy presented with a 2 week history of w...
متن کاملLithium-related neurotoxicity despite serum concentrations in the therapeutic range: risk factors and diagnosis
We would like to comment on the interesting case report of lithium intoxication reported by Jing Peng. An 18-year old female with mania developed confusion, trembling extremities, slurred speech, increased muscle tension, and hyperactive tendon reflexes 20 days after initiating treatment with routine dosages of lithium bicarbonate. When admitted to the hospital due to her acute neurological con...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 22 شماره
صفحات -
تاریخ انتشار 1980